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A template for constructing Bayesian networks in forensic biology cases when considering activity level propositions

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Opportunities and challenges in design and optimization of protein function

Bruno Emanuel Ferreira De Sousa Correia, Casper Alexander Goverde

The field of protein design has made remarkable progress over the past decade. Historically, the low reliability of purely structure-based design methods limited their application, but recent strategies that combine structure-based and sequence-based calcu ...

Nature Portfolio2024

Intermediate Address Space: virtual memory optimization of heterogeneous architectures for cache-resident workloads

David Atienza Alonso, Marina Zapater Sancho, Luis Maria Costero Valero, Darong Huang, Qunyou Liu

The increasing demand for computing power and the emergence of heterogeneous computing architectures have driven the exploration of innovative techniques to address current limitations in both the compute and memory subsystems. One such solution is the use ...

2024

Towards improving full-length ribosome density prediction by bridging sequence and graph-based representations

Pierre Vandergheynst, Felix Naef, Cédric Gobet, Francesco Craighero, Mohan Vamsi Nallapareddy

Translation elongation plays an important role in regulating protein concentrations in the cell, and dysregulation of this process has been linked to several human diseases. In this study, we use data from ribo-seq experiments to model ribosome densities, ...

PMLR2024

Investigating the intra-molecular and inter-molecular effects of post-translational modifications on intrinsically disordered protein regions and structured protein regions

Zhidian Zhang

Post-translational modifications (PTMs) play a pivotal role in regulating protein structure, interaction, and function. Aberrant PTM patterns are associated with diseases. Moreover, individual PTMs have a complex interaction with each other, known as PTM c ...

EPFL2024

Toroidal families and averages of L-functions, I

Philippe Michel

We initiate the study of certain families of L-functions attached to characters of subgroups of higher-rank tori, and of their average at the central point. In particular, we evaluate the average of the values L( 2 1 , chi a )L( 21 , chi b ) for arbitrary ...

Polish Acad Sciences Inst Mathematics-Impan2024

Evaluation and digitalization: what are the key challenges for evaluation processes and evaluators?

Omar Ballester Gonzalez

Public policy evaluation has traditionally been conducted in a context constrained by legal, institutional and political red tape. The arrival of digitalisation adds a new layer to public policy evaluation processes. Assessing the quality of technologies, ...

Edward Elgar Publishing2023

Periodic and aperiodic NiFe nanomagnet/ferrimagnet hybrid structures for 2D magnon steering and interferometry with high extinction ratio

Dirk Grundler, Sho Watanabe, Andrea Mucchietto, Shixuan Shan, Elif Nur Dayi, Vinayak Shantaram Bhat

File formats are described in read_me files in the concerning folder. For plotting and data evaluation, Python 2.7 was used. Example scripts for plotting are provided. ...

Zenodo2023

Towards Novel Evaluation Methods for Social Dialog Systems

Ekaterina Svikhnushina

Language has shaped human evolution and led to the desire to endow machines with language abilities. Recent advancements in natural language processing enable us to achieve this breakthrough in human-machine interaction. However, introducing conversational ...

EPFL2023

Entrepreneurial Opportunities and Threats in the Era of Grand Societal Challenges

Enrico Bergamini

We live in an era defined by attempts to grapple with an ever-expanding array of grand societal challenges (GCs). These challenges comprise transformational social and environmental issues, such as environmental degradation and global pandemics, and the cr ...