Neural dynamics of the competition between grouping organizations

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Mesoscopic description of hippocampal replay and metastability in spiking neural networks with short-term plasticity

Tilo Schwalger, Valentin Marc Schmutz

Bottom-up models of functionally relevant patterns of neural activity provide an explicit link between neuronal dynamics and computation. A prime example of functional activity patterns are propagating bursts of place-cell activities called hippocampal rep ...

PUBLIC LIBRARY SCIENCE2022

Breathing is coupled with voluntary initiation of mental imagery

Olaf Blanke, Oliver Alan Kannape, Hyeongdong Park

Previous research has suggested that bodily signals from internal organs are associated with diverse cortical and subcortical processes involved in sensory-motor functions, beyond homeostatic reflexes. For instance, a recent study demonstrated that the pre ...

ACADEMIC PRESS INC ELSEVIER SCIENCE2022

Inventory of Problems: The Genesis of the Rotterdam Kunsthal by OMA/Rem Koolhaas, 1987-1992

Tibor Bonaventura Pataky

The Kunsthal in Rotterdam is a key work in the oeuvre of OMA/Rem Koolhaas that marks the threshold between the firmâ s architectural production of the decades before and after 1990. This doctoral thesis aims at a deeper and comprehensive understanding of ...

EPFL2021

The shine-through paradigm and the schizophrenia spectrum: a summary

Michael Herzog, Simona Adele Garobbio, Maya Roinishvili, Ophélie Gladys Favrod, Janir Nuno Ramos Antunes Da Cruz

In the past 10 years, our laboratory has proved the shine-through paradigm to be a very sensitive endophenotype for schizophrenia. The shine-through paradigm is a visual backward masking task, where the target is a vertical vernier followed by a 25-element ...

2021

Price-based regulation of oligopolistic markets under discrete choice models of demand

Michel Bierlaire, Virginie Janine Camille Lurkin, Stefano Bortolomiol

We propose a framework to find optimal price-based policies to regulate markets characterized by oligopolistic competition and in which consumers make a discrete choice among a finite set of alternatives. The framework accommodates general discrete choice ...

2022

The genetic architecture of complex human traits at the dawn of genomic medicine

Olivier Noël Marie Naret

The focus of the work presented in this thesis is the exploration of the genetic architecture of complex human traits - at the dawn of genomic medicine. The underlying mechanisms explaining the enormously polygenic nature of most human complex traits are ...

EPFL2021

In Vitro-Evolved Peptides Bind Monomeric Actin and Mimic Actin-Binding Protein Thymosin-β4

Christian Heinis, Jonas Alfred Karl Wilbs, Davide Bertoldo, Ganesh Kumar Mothukuri, Raphael Johannes Gübeli

Actin is the most abundant protein in eukaryotic cells and is key to many cellular functions. The filamentous form of actin (F-actin) can be studied with help of natural products that specifically recognize it, as for example fluorophore-labeled probes of ...

2021

GRASP55 regulates intra-Golgi localization of glycosylation enzymes to control glycosphingolipid biosynthesis

Giovanni D'Angelo, Charlotte Julie Caroline Gehin, Laura Capolupo, Riccardo Rizzo

The Golgi apparatus, the main glycosylation station of the cell, consists of a stack of discontinuous cisternae. Glycosylation enzymes are usually concentrated in one or two specific cisternae along the cis-trans axis of the organelle. How such compartment ...

WILEY2021

Decoding of error-related potentials in continuous feedback protocols for personalized human computer interaction

Fumiaki Iwane

The ability to notice erroneous behavior is crucial for effective training. Within the framework of neuroprosthetics, numerous studies in electroencephalography (EEG) confirm the existence of neural correlates when humans perceive the erroneous actions of ...

EPFL2021

Neural Compensation Mechanisms of Siblings of Schizophrenia Patients as Revealed by High-Density EEG

Michael Herzog, Maya Roinishvili, Ophélie Gladys Favrod, Janir Nuno Ramos Antunes Da Cruz, Patricia Figueiredo, Albulena Jashari-Shaqiri

Visual backward masking (VBM) deficits are candidate endophenotypes of schizophrenia indexing genetic liability of the disorder. In VBM, a target is followed by a mask that deteriorates target perception. Schizophrenia patients and, to a lesser extent, the ...

2020

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