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Opportunities for Targeting the Angiotensin-Converting Enzyme 2/Angiotensin-(1-7)/Mas Receptor Pathway in Hypertension

Publications associées (28)

Effect of the structural modification of Candesartan with Zinc on hypertension and left ventricular hypertrophy

Nikolaos Stergiopoulos, Augusto Martins Lima, Valeria Romina Martinez

Hypertension is the most common cause of left ventricular hypertrophy, contributing to heart failure progression. Candesartan (Cand) is an angiotensin receptor antagonist widely used for hypertension treatment. Structural modifications were previously perf ...

ELSEVIER2023

Modulation of Pulsatile Left Ventricular Afterload by Renal Denervation in Heart Failure With Preserved Ejection Fraction

Nikolaos Stergiopoulos, Stamatia Zoi Pagoulatou

Background:Arterial stiffening contributes to hemodynamic derangements in heart failure with preserved ejection fraction (HFpEF). We sought to investigate the impact of renal denervation on pulsatile left ventricular loading in patients with HFpEF and hype ...

Lippincott Williams & Wilkins2023

Design and computational optimization of compliance-matching aortic grafts

Nikolaos Stergiopoulos, Georgios Rovas, Vasiliki Bikia

Introduction: Synthetic vascular grafts have been widely used in clinical practice for aortic replacement surgery. Despite their high rates of surgical success, they remain significantly less compliant than the native aorta, resulting in a phenomenon calle ...

FRONTIERS MEDIA SA2023

Altered heart cytokine profile and action potential modulation in cardiomyocytes from Mas-deficient mice

The renin-angiotensin system (RAS) is a key hormonal system. In recent years, the functional analysis of the novel axis of the RAS (ACE2/Ang-(1-7)/Mas receptor) revealed that its activation can become pro-tective against several pathologies, including card ...

ACADEMIC PRESS INC ELSEVIER SCIENCE2022

Acute and Long-Term Effects of Aortic Compliance Decrease on Central Hemodynamics: A Modeling Analysis

Nikolaos Stergiopoulos, Georgios Rovas, Vasiliki Bikia, Stamatia Zoi Pagoulatou

Aortic compliance is an important determinant of cardiac afterload and a contributor to cardiovascular morbidity. In the present study, we sought to provide in silico insights into the acute as well as long-term effects of aortic compliance decrease on cen ...

FRONTIERS MEDIA SA2021

The effect of left ventricular contractility on arterial hemodynamics: A model-based investigation

Nikolaos Stergiopoulos, Georgios Rovas, Vasiliki Bikia, Stamatia Zoi Pagoulatou

Ventricular-arterial coupling is a major determinant of cardiovascular performance, however, there are still inherent difficulties in distinguishing ventricular from vascular effects on arterial pulse phenotypes. In the present study, we employed an extens ...

2021

Non-invasive monitoring of key hemodynamical and cardiac parameters using physics-based modelling and artificial intelligence

Vasiliki Bikia

In a progressively aging population, it is of utmost importance to develop reliable, non-invasive, and cost-effective tools to estimate biomarkers that can be indicative of cardiovascular risk. Clinical parameters directly measured in the heart or the aort ...

EPFL2021

Distinct types of plexiform lesions identified by synchrotron-based phase-contrast micro-CT

Goran Lovric

In pulmonary arterial hypertension, plexiform lesions are associated with severe arterial obstruction and right ventricular failure. Exploring their structure and position is crucial for understanding the interplay between hemodynamics and vascular remodel ...

AMER PHYSIOLOGICAL SOC2021

On the assessment of arterial compliance from carotid pressure waveform

Nikolaos Stergiopoulos, Georgios Rovas, Vasiliki Bikia, Stamatia Zoi Pagoulatou, Patrick Segers

In a progressively aging population, it is of utmost importance to develop reliable, noninvasive, and cost-effective tools to estimate biomarkers that can be indicative of cardiovascular risk. Various pathophysiological conditions are associated to changes ...

AMER PHYSIOLOGICAL SOC2021

Opportunities for Targeting the Angiotensin-Converting Enzyme 2/Angiotensin-(1-7)/Mas Receptor Pathway in Hypertension

Effect of the structural modification of Candesartan with Zinc on hypertension and left ventricular hypertrophy

Modulation of Pulsatile Left Ventricular Afterload by Renal Denervation in Heart Failure With Preserved Ejection Fraction

Design and computational optimization of compliance-matching aortic grafts

Altered heart cytokine profile and action potential modulation in cardiomyocytes from Mas-deficient mice

Acute and Long-Term Effects of Aortic Compliance Decrease on Central Hemodynamics: A Modeling Analysis

The effect of left ventricular contractility on arterial hemodynamics: A model-based investigation

Non-invasive monitoring of key hemodynamical and cardiac parameters using physics-based modelling and artificial intelligence

Distinct types of plexiform lesions identified by synchrotron-based phase-contrast micro-CT

On the assessment of arterial compliance from carotid pressure waveform

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Effect of the structural modification of Candesartan with Zinc on hypertension and left ventricular hypertrophy

Modulation of Pulsatile Left Ventricular Afterload by Renal Denervation in Heart Failure With Preserved Ejection Fraction

Design and computational optimization of compliance-matching aortic grafts

p-Aminobenzamidine attenuates cardiovascular dysfunctions in spontaneously hypertensive rats

Altered heart cytokine profile and action potential modulation in cardiomyocytes from Mas-deficient mice

Acute and Long-Term Effects of Aortic Compliance Decrease on Central Hemodynamics: A Modeling Analysis

The effect of left ventricular contractility on arterial hemodynamics: A model-based investigation

Non-invasive monitoring of key hemodynamical and cardiac parameters using physics-based modelling and artificial intelligence

Distinct types of plexiform lesions identified by synchrotron-based phase-contrast micro-CT

On the assessment of arterial compliance from carotid pressure waveform

p-Aminobenzamidine attenuates cardiovascular dysfunctions in spontaneously hypertensive rats