Variant of uncertain significanceA variant of uncertain (or unknown) significance (VUS) is a genetic variant that has been identified through genetic testing but whose significance to the function or health of an organism is not known. Two related terms are "gene of uncertain significance" (GUS), which refers to a gene that has been identified through genome sequencing but whose connection to a human disease has not been established, and "insignificant mutation", referring to a gene variant that has no impact on the health or function of an organism.
Future historyA future history is a postulated history of the future and is used by authors of science fiction and other speculative fiction to construct a common background for fiction. Sometimes the author publishes a timeline of events in the history, while other times the reader can reconstruct the order of the stories from information provided therein. The term appears to have been coined by John W. Campbell, Jr., the editor of Astounding Science Fiction, in the February 1941 issue of that magazine, in reference to Robert A.
