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Redox and Immune Signaling in Schizophrenia: New Therapeutic Potential

Lijing Xin, Kim Do, Daniella Dwir

Redox biology and immune signaling play major roles in the body, including in brain function. A rapidly growing literature also suggests that redox and immune abnormalities are implicated in neuropsychiatric conditions such as schizophrenia (SZ), bipolar d ...

OXFORD UNIV PRESS2023

20-years work investigating the shine-through paradigm in the schizophrenia spectrum: what is next?

Michael Herzog, Simona Adele Garobbio, Maya Roinishvili

In the past 20 years, our laboratory has proved the shine-through paradigm to be a very sensitive endophenotype for schizophrenia. The shine-through paradigm is a visual backward masking task, where the target is a vertical vernier followed by a 25-element ...

2023

Human PBMCs Form Lipid Droplets in Response to Spike Proteins

Florian Maria Wurm, Guillaume Raussin

Intracellular lipid droplets (LDs) can accumulate in response to inflammation, metabolic stresses, and other physiological/pathological processes. Herein, we investigated whether spike proteins of SARS-CoV-2 induce LDs in human peripheral blood mononuclear ...

Basel2023

Emotional sounds in space: asymmetrical representation within early-stage auditory areas

Stephanie Clarke

Evidence from behavioral studies suggests that the spatial origin of sounds may influence the perception of emotional valence. Using 7T fMRI we have investigated the impact of the categories of sound (vocalizations; non-vocalizations), emotional valence (p ...

FRONTIERS MEDIA SA2023

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The central nervous system develops from a pool of neural progenitors which, depending on their location and time of division, generate cells committed to differentiate into specific kinds of neurons or glia. In the last decades, the developmental neurobio ...

Amsterdam2023

NMDA-driven dendritic modulation enables multitask representation learning in hierarchical sensory processing pathways

Willem Anna Mark Wybo, Bernd Albert Illing, Matthias Chinyen Tsai, Walter Senn

While sensory representations in the brain depend on context, it remains unclear how such modulations are implemented at the biophysical level, and how processing layers further in the hierarchy can extract useful features for each possible contex-tual sta ...

Washington2023

Brain microstructural and functional MRI: developments and application to a rat model of Alzheimer's disease

Yujian Diao

Magnetic resonance imaging (MRI) has been a valuable tool in investigating the pathological cascade of Alzheimer's disease (AD) and its progression, which are still open questions. Although some MRI-derived hallmarks in terms of functional connectivity and ...

EPFL2023

Hydrogels and conductive hydrogels for implantable bioelectronics

Stéphanie Lacour, Outman Akouissi, Emilio Fernández Lavado, Massimo Mariello, Kutay Sagdic

Hydrogels are a class of soft materials, which display unique biomimetic properties to biological tissues. Their mechanical properties, high water content, and porosity resemble that of extracellular matrix so that cell growth and proliferation can be reli ...

2023

Theta oscillations and minor hallucinations in Parkinson’s disease reveal decrease in frontal lobe functions and later cognitive decline

Olaf Blanke, Fosco Bernasconi

Cognitive decline and hallucinations are common and debilitating non-motor symptoms, usually occurring during later phases of Parkinson’s disease (PD). Minor hallucinations (MH) appear early in the disease course and have been suggested to predict cognitiv ...

2023

Bioaccumulation and molecular effects of carbamazepine and methylmercury co-exposure in males of Dreissena polymorpha

Florian Frédéric Vincent Breider, Dominique Grandjean, Nguyên Thiên Kim Lê, Claudia Cosio

Dreissena polymorpha is a bivalve promising for biomonitoring in freshwater ecosystems thanks to its abundance and high filtration activity allowing rapid uptake of toxicants and identification of their negative effects. Nonetheless, we still lack knowledg ...

2023

Theta oscillations and minor hallucinations in Parkinson’s disease reveal decrease in frontal lobe functions and later cognitive decline

Olaf Blanke, Fosco Bernasconi

2023

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Amsterdam2023

Heterogeneity and developmental dynamics of mammalian neocortical progenitors

Gioele La Manno

Antonio Herrera Camacho

Leila Haj Abdullah Alieh