Unité
Laboratoire de biomatériaux pour l'immuno-ingénierie
LaboratoirePublications associées (112)
Highly effective adoptive t cell therapy
Li Tang, Yugang Guo, Bing Feng
The present invention relates generally to the field of anti-cancer therapy and autoimmune therapy, in particular to the use of adoptive T cell transfer therapy. More specifically, the present invention relates to compositions, pharmaceutical compositions ...
2023Mechanical Immunoengineering of T Cells for Enhanced Cancer Immunotherapy
Cancer is one of the leading causes of death globally. Immunotherapy represents one of the most promising cancer treatments inducing complete and durable responses in a fraction of cancer patients. Despite the unprecedented clinical success achieved by T c ...
EPFL2022Immunosuppressive roles of Activin-A in melanoma and characterization of its precursor cleavage
Activin-A, a transforming growth factor êµ family member, is a pleiotropic cytokine with diverse functions in development, fertility, adult tissue homeostasis, and aging. Accordingly, deregulation of Activin-A signaling has been associated with many patho ...
EPFL2022Aberrant hyperexpression of the RNA binding protein FMRP in tumors mediates immune evasion
Douglas Hanahan, Nadine Fournier, Krisztian Homicsko, Mélanie Louise Tichet, Agnieszka Alicja Chryplewicz, Jeremy Gilles Louis Guillot, Simge Yücel, Mohammad Sadegh Saghafinia, Inti Zlobec, Yuqing Xie, Dalya Ataca, Qiqun Zeng, Fleuriane Marie Tryskele Laurene Gallean, Peng Zhang, Lucine Christe
Many human cancers manifest the capability to circumvent attack by the adaptive immune system. In this work, we identified a component of immune evasion that involves frequent up-regulation of fragile X mental retardation protein (FMRP) in solid tumors. FM ...
Washington2022The role of eosinophils in breast cancer
Eosinophils are granulocytes and belong to the innate arm of immunity. Eosinophils can be in different basal or activation states and depending on which type of activation is applied, they exert different effector functions. These multi-functional cells ha ...
EPFL2022Engineering T Cell Trafficking and Function for Enhanced Cancer Immunotherapy
In the past decades, breakthroughs in cancer immunotherapy have led to unprecedented clinical responses in patients with advanced-stage cancers that would otherwise be fatal. However, treatment of many solid organ malignancies with highly immunosuppressive ...
EPFL2022BCG hydrogel promotes CTSS-mediated antigen processing and presentation, thereby suppressing metastasis and prolonging survival in melanoma
Li Tang, Bing Feng, Thomas Gruber
Background The use of intralesional Mycobacterium bovis BCG (intralesional live BCG) for the treatment of metastatic melanoma resulted in regression of directly injected, and occasionally of distal lesions. However, intralesional-BCG is less effective in p ...
BMJ PUBLISHING GROUP2022Dendritic cell cross-dressing and tumor immunity
Michele De Palma, Amaia Martinez Usatorre
In addition to direct and cross-presentation, dendritic cells (DCs) can present tumor antigens (TAs) to T cells via a hitherto poorly understood mechanism called "cross-dressing." DC cross-dressing involves the acquisition of preformed peptide-major histoc ...
WILEY2022The cGAS-STING pathway and cancer
Andrea Ablasser, Natasha Ella Samson
The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway has emerged as a critical innate immune pathway that, following engagement by DNA, promotes distinct immune effector responses that can impact virtually all aspects of tumori ...
NATURE PORTFOLIO2022Soft cancer cells squeeze through T cell's grip
Li Tang, Armand Kurum, Yi Wang
Immune cells are exquisitely sensitive to the mechanical properties of cancer cells. Soft cancer cells can avoid immune-mediated destruction. Therapeutically targeting this mechanical immune checkpoint may enhance the efficacy of cancer immunotherapy. ...
ELSEVIER2022