Unité
Laboratoire de neurobiologie moléculaire et neuroprotéomique
LaboratoirePublications associées (1 000)
Investigating the intra-molecular and inter-molecular effects of post-translational modifications on intrinsically disordered protein regions and structured protein regions
Post-translational modifications (PTMs) play a pivotal role in regulating protein structure, interaction, and function. Aberrant PTM patterns are associated with diseases. Moreover, individual PTMs have a complex interaction with each other, known as PTM c ...
EPFL2024From Sequence to Dynamics to Function: Computational Design of Allostery and Ligand Selectivity in G-Protein Coupled Receptors
The phenomenon of allostery, a general property in proteins that has been heralded as "the second secret of life" remains elusive to our understanding and even more challenging to incorporate into protein design. One example of allosteric proteins with gre ...
EPFL2024Targeting TDP-43 Proteinopathies in Neurodegeneration by its Native-State Stabilization.
Preventing the misfolding or aggregation of TDP-43 is the most actively pursued disease-modifying strategy to treat amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. In our work, we provide proof of concept that native state stabili ...
EPFL2024Distinct ultrastructural phenotypes of glial and neuronal alpha-synuclein inclusions in multiple system atrophy
Henning Paul-Julius Stahlberg, Amanda Jennifer Lewis, Marta Di Fabrizio, Domenic Burger, Carolin Böing
Multiple System Atrophy is characterized pathologically by the accumulation of alpha-synuclein (aSyn) into glial cytoplasmic inclusions (GCIs). The mechanism underlying the formation of GCIs is not well understood. In this study, correlative light and elec ...
2024The CRL5-SPSB3 ubiquitin ligase targets nuclear cGAS for degradation
Andrea Ablasser, Baptiste Claude André Guey, Jonathan Jean-Pierre Ricci, Chong Liu, Pauline Ambre Melenec, Pengbiao Xu, Lingyun Li, Ying Liu
Cyclic GMP-AMP synthase (cGAS) senses aberrant DNA during infection, cancer and inflammatory disease, and initiates potent innate immune responses through the synthesis of 2 ' 3 '-cyclic GMP-AMP (cGAMP)1-7. The indiscriminate activity of cGAS towards DNA d ...
Nature Portfolio2024Predicting protein interactions using geometric deep learning on protein surfaces
In the domain of computational structural biology, predicting protein interactions based on molecular structure remains a pivotal challenge. This thesis delves into this challenge through a series of interconnected studies.The first chapter introduces the ...
EPFL2024Drug Screening in C. elegans to identify new pharmacological mitochondrial stress inducers
Mitochondria are essential organelles participating in numerous cellular functions, including energy harvesting, regulation of homeostasis and apoptosis. Changes in mitochondrial number, morphology, and function not only impact cellular metabolism but also ...
EPFL2024Membrane specificity of the human cholesterol transfer protein STARD4
Charlotte Julie Caroline Gehin
STARD4 regulates cholesterol homeostasis by transferring cholesterol between the plasma membrane and endoplasmic reticulum. The STARD4 structure features a helix-grip fold surrounding a large hydrophobic cavity holding the sterol. Its access is controlled ...
Academic Press Ltd- Elsevier Science Ltd2024Structure-function analysis of the cyclic β-1,2-glucan synthase from Agrobacterium tumefaciens
Henning Paul-Julius Stahlberg, Dongchun Ni
The synthesis of complex sugars is a key aspect of microbial biology. Cyclic beta-1,2-glucan (C beta G) is a circular polysaccharide critical for host interactions of many bacteria, including major pathogens of humans (Brucella) and plants (Agrobacterium). ...
Nature Portfolio2024Autorepression of yeast Hsp70 cochaperones by intramolecular interactions involving their J-domains
Paolo De Los Rios, Pierre Goloubinoff, Satyam Tiwari, Mathieu Rebeaud, Bruno Claude Daniel Fauvet, Adélaïde Alice Mohr
The 70 kDa heat shock protein (Hsp70) chaperones control protein homeostasis in all ATP-containing cellular compartments. J-domain proteins (JDPs) coevolved with Hsp70s to trigger ATP hydrolysis and catalytically upload various substrate polypeptides in ne ...
Elsevier Science Inc2024