Unité

Unité du Prof. Lutolf

Laboratoire

Publications associées (1 000)

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The invention provides microfluidic screening systems for the identification of compounds or compositions influencing cellular transcriptomes. The invention is predicated upon taking into account differences in newly synthesized mRNA in contrast to so call ...

2024

Metabolically enhanced CAR T cells efficiently clear solid tumors in mice

Li Tang

Chimeric antigen receptor (CAR) T cells in the solid tumor microenvironment enter a partially dysfunctional state called T cell exhaustion. Interleukin (IL)-10-producing CAR T cells retain their metabolic fitness, resist T cell exhaustion and display unpre ...

Berlin2024

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Among the inherited myopathies, a group of muscular disorders characterized by structural and metabolic impairments in skeletal muscle, Duchenne muscular dystrophy (DMD) stands out for its devastating progression. DMD pathogenesis is driven by the progress ...

Wiley2024

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With its exceptional biocompatibility, alginate emerged as a highly promising biomaterial for a large range of applications in regenerative medicine. Whether in the form of microparticles, injectable hydrogels, rigid scaffolds, or bioinks, alginate provide ...

2024

An artificial urinary sphincter based on dielectric elastomer technology

Yves Perriard, Yoan René Cyrille Civet, Stefania Maria Aliki Konstantinidi, Amine Benouhiba, Quentin Philippe Mario De Menech, Sloan Zammouri

Urinary incontinence (UI) is prevalent and distressing medical condition affecting millions of patients worldwide. Current treatment options for severe cases often involve surgical intervention, such as the implantation of an artificial urinary sphincter ( ...

Society of Photo-Optical Instrumentation Engineers (SPIE)2024

Bioengineered Tubular Biliary Organoids

Matthias Lütolf, Bilge Sen Elçi, Saba Rezakhani, Mikhail Nikolaev

Liver organoids have emerged as promising in vitro models for toxicology, drug discovery, and disease modeling. However, conventional 3D epithelial organoid culture systems suffer from significant drawbacks, including limited culture duration, a nonphysiol ...

Hoboken2024

System for micturition control in a mammal with bladder disfunction

Grégoire Courtine, Jocelyne Bloch, Jordan Squair

The present invention relates to a neuromodulation/neurostimulation system (10) for stimulating at least one neuronal circuitry responsible for micturition control in a mammal with bladder disfunction, especially for bladder relaxation and/or for bladder v ...

2024

A microbial-derived succinylated bile acid to safeguard liver health

Kristina Schoonjans, Alessia Perino, Hadrien Charles Edouard Demagny

In this issue of Cell, Nie and co-authors report that the microbe-derived bile acid (BA) 3-succinylated cholic acid protects against the progression of metabolic dysfunction-associated liver disease. Intriguingly, its protective mechanism does not involve ...

Cell Press2024

Bioengineering human mini-intestines with in vivo-like complexity and function

Olga Mitrofanova

Biological research heavily relies on the use of animal models, which has made it difficult to answer specific questions about human biology and disease. However, with the advent of human organoids - miniature versions of tissues generated in 3D human stem ...

EPFL2023

A single-cell-based characterization of mammalian adipose stem and progenitor cell heterogeneity and function

Pernille Yde Rainer

White adipose tissue (WAT) is a cellularly heterogeneous endocrine organ that not only serves as a reservoir for storing and releasing energy but also actively participates in metabolic homeostasis. Given the current rise in obesity and its associated com ...

EPFL2023