Protein Design: Cytokine Stability & Biosensors

This lecture delves into the design of protein structures, focusing on the stability and function of cytokines. The study explores the denovo design of a cytokine ligand that binds selectively to specific receptor subunits, enhancing stability and signaling. Additionally, the lecture discusses the application of protein design in biosensors, showcasing the development of ligand-binding proteins for immune cell activation. The use of computational models and directed evolution to optimize protein structures is highlighted, along with the potential for future advancements in protein engineering.