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This lecture by the instructor covers the nanoscale design for large-scale challenges, focusing on new technologies for efficient power devices, effective thermal management, and faster electronics. The content includes the establishment of the POWER lab at EPFL, the motivation behind the research, the challenges faced in power conversion efficiency, the use of GaN as an exceptional material for power devices, the development of lateral and vertical power devices, and the exploration of epitaxial growth for GaN and Diamond. The lecture also delves into the advancements in high power density converters, the potential of GaN-on-Si power integrated circuits, and the challenges and solutions for GaN-on-Si power devices.