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This lecture covers the characteristics and operation of Organic Thin Film Transistors (OTFTs), focusing on ideal characteristics, mobility, threshold voltage, and static figures of merit. It also discusses the impact of stress on lifetime and the concept of ambipolar transport in conjugated materials. The presentation includes examples of OTFT applications in printed sensors for skin/wearable devices and the design challenges for more complex circuits. The instructor emphasizes the need for continuous improvement in material properties and the potential for flexible/disposable systems in various domains.