Protein Quality Control of Membraneless Organelles

This lecture explores the protein quality control mechanisms of membraneless organelles, focusing on the implications for stress responses and age-related diseases. It covers the formation of membraneless organelles through liquid-liquid phase separation, the role of multivalent proteins and disordered proteins, and the conversion of proteins into amyloid-like deposits. The lecture also discusses the impact of disease-linked mutations on the maturation of liquid droplets. Furthermore, it delves into the cellular protein quality control system, the role of chaperones, and the clearance of misfolded proteins. The consequences of protein mishandling, the formation of stress granules, and the interplay between nucleoli functionality and protein aggregation are also addressed.