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This lecture explores the impact of prior knowledge on learning, discussing how existing knowledge can aid or hinder the acquisition of new information. It delves into the organization of new information, the role of practice and repetition, and the negative effects of misconceptions. The session also covers the network model of long-term memory, differences between experts and novices in integrating new information, and the importance of encoding, storage, and retrieval. Various research evidence and strategies for effective learning, such as concept maps and deliberate practice, are presented to enhance understanding and retention of information.