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DNA Repair Mechanisms
This lecture covers the mechanisms of DNA repair, focusing on base excision repair (BER) and nucleotide excision repair (NER). It discusses the roles of various enzymes and factors involved in repairing damaged DNA, such as glycosylases, endonucleases, and polymerases. The lecture also explores the cellular responses to replicative stress and DNA double-strand breaks, including the activation of checkpoint kinases ATM and ATR. Additionally, it delves into the genetic disorders Ataxia Telangiectasia and Seckel Syndrome, highlighting their impact on DNA repair mechanisms and cancer susceptibility.