DNA Repair Mechanisms

This lecture covers DNA repair mechanisms, focusing on Base Excision Repair (BER), Mismatch Repair (MMR), Nucleotide Excision Repair (NER), and other related processes. It discusses the roles of various proteins and enzymes involved in repairing DNA damage, such as polymerases and ligases. The lecture also delves into the repair of double-strand breaks through Non-homologous End Joining (NHEJ) and Homologous Recombination (HR). Additionally, it explores the impact of UV-induced lesions on DNA, the consequences of repair deficiencies like Xeroderma Pigmentosum, and the mechanisms of resistance to PARP inhibitors in cancer therapy.