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This lecture introduces the concept of synaptic plasticity, exploring its forms, properties in the hippocampus, network-level oscillations, and the impact of neuromodulators. It covers the basic anatomy of the hippocampus, types of synapses, Hebb's postulate, and the discovery of long-term potentiation (LTP) and depression (LTD). The lecture also discusses the properties of LTP and LTD, the association of LTP with network oscillations in the hippocampus, and the experimental models used to study them.