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This lecture delves into the complexities of mental health, emphasizing that it is more than just the absence of disorders. It explores the World Health Organization's definition of health and the importance of mental well-being. The lecture covers various risk and protective factors, the high costs associated with mental health conditions, and the impact of stress and depression. It also discusses the global burden of mental disorders, the role of socioeconomic factors in mental health, and the rising cases of dementia worldwide. Additionally, it touches on the relationship between urban living and mental health, the biological determinants of creativity and psychopathology, and the implications of precision medicine in psychiatry.