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This lecture covers the sources of noise in electrical systems, including thermal, shot, and flicker noise, as well as the physics behind thermal noise and the Fluctuation-Dissipation Theorem. It also delves into amplifier noise, interference, and the impact of noise on signal quality, with examples of noise calculations and the role of preamplifiers. The lecture further explores the concepts of quantifying noise, tags, and noise temperature, along with the effects of interference such as EMI, ground loops, and magnetic induction. Additionally, it discusses the quantization error in ADCs and the implications of interference on signal processing.