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This lecture covers the physical models for micro and nanosystems, focusing on X and gamma-ray imaging devices. It discusses the uses of X-ray detectors in medical imaging and security scanners, as well as the sources and architecture of X and gamma-ray detectors. The lecture also explores semiconductor, gas, and scintillation detectors, highlighting their working principles and materials used. Additionally, it delves into main detector parameters such as energy resolution and detection efficiency, providing insights into signal current, induced charge, and Ramo's theorem for charge transport applications.