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This lecture delves into the intricate workings of the somatosensory system, exploring the diverse sensations it mediates, from touch to pain. It covers the anatomy and function of this system, the types of mechanoreceptors in the skin, and the process of sensory transduction. The presentation also discusses the Nobel Prize-winning discoveries related to receptors for temperature and touch, as well as the importance of proprioception. Through detailed illustrations and examples, the lecture elucidates how sensory information is transmitted and processed in the central nervous system, shedding light on the mechanisms underlying our ability to perceive and respond to various stimuli.