Sphingolipid Synthesis

This lecture covers the synthesis of sphingolipids, a class of lipids with a backbone of sphingoid bases, including sphingosine. The process involves the formation of ceramide, which can be glycosylated to produce various glycosphingolipids. The synthesis occurs through de novo and salvage pathways, with enzymes like serine-palmitoyltransferase and ceramide synthases playing crucial roles. The lecture also delves into the regulation of ceramide synthesis and the conversion of ceramide into sphingomyelin. Additionally, it explores the biosynthesis of glucosylceramide and other complex glycosphingolipids in the Golgi apparatus.