Protein Lipidation: Membrane Localization and Signalling

This lecture discusses the process of protein lipidation, focusing on the (ir)reversible attachment of proteins to membranes. The instructor covers topics such as localizing proteins within membranes, different lipidation types like GPI anchors and prenylation, major classes of membrane lipids, and the modulation of signaling pathways. The lecture also explores lipid asymmetry in eukaryotic membranes, phase separations for sorting and transport, and the dynamic nature of protein lipidation. Additionally, it delves into the role of lipid rafts in biological lateral phase separations, the modulation of GPCR signaling by lipid domains, and the signaling cascade of CD59. The session concludes with insights into the localization and signaling of proteins in membranes through lipidation.