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This lecture covers the motor cortex and basal ganglia, discussing the control of movement, spinal motor neurons, primary motor cortex characteristics, the corticospinal tract, mirror neurons, brain-machine interfaces, and the role of the basal ganglia in movement initiation and suppression. It also explores the pathways involved in action selection, the clinical relevance of Parkinson's and Huntington's diseases, and deep brain stimulation for Parkinson's treatment.