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This lecture covers the fundamentals of analog and digital systems, focusing on sensor treatment, electronic physics, and signal conditioning. It explores the design of voltage amplifiers, filters, comparators, and signal conditioning blocks. Additionally, it delves into applications in transport, mobility, and connectivity, including IoT and 5G technologies. The lecture also discusses the role of sensors in various domains such as healthcare, transportation, and environmental monitoring. Practical aspects of electronic systems design and evaluation are emphasized, with a particular focus on laboratory work and theoretical preparation.