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This lecture covers the engineering of neurons using light, chemicals, and sound. It delves into the basics of neural activity, action potentials, and the interaction between brain and behavior. The presentation progresses to the advanced techniques of optogenetics, chemogenetics, and sonogenetics, showcasing how these methods can modulate neural activity. The lecture highlights the significance of controlling brain-circuit activity to influence behavior, providing insights into the tools and concepts behind these cutting-edge technologies.