This lecture delves into the biophysical understanding of neuronal electrical behavior, exploring the structure and functional implications of neurons, myelin sheath, axons, and synaptic terminals. It covers the challenges in modeling neurons, the different levels of abstraction, and the role of ion channels in cellular computations. The lecture discusses the generation of action potentials, the Hodgkin-Huxley neuron models, and the cable theory for understanding electrical behavior in neurons. It also highlights the impact of dendritic structure on firing patterns and the principles governing synaptic inhibition in dendrites, providing insights into how inhibition controls dendritic excitability and plasticity.