Deleterious Phase Transitions in ALS/FTD

This lecture by the instructor covers the relationship between amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), focusing on the signs, symptoms, and genetic overlap between the two neurodegenerative diseases. It delves into the formation of cytoplasmic inclusions by TDP-43 and FUS, RNA-binding proteins with prion-like domains, and the role of Kapß2 in disassembling FUS fibrils. The lecture also explores the potential therapeutic strategies involving protein disaggregases and the prevention of aberrant phase transitions in ALS/FTD.