Neuroepigenetics: Chromatin Structure and Regulation

This lecture explores neuroepigenetics, focusing on chromatin structure and regulation. It covers topics such as chromatin condensation, regulation of chromatin structure, and epigenetic inheritance. The lecture delves into the dynamic nature of nucleosomes, the 30nm chromatin fiber, and the impact of histone posttranslational modifications on transcription. It also discusses the role of DNA methylation in gene repression and the influence of environmental factors on epigenetic inheritance. The presentation highlights the importance of histone variants, insulators, and barriers in maintaining chromatin integrity. Additionally, it examines the interplay between epigenetic modifications and genetic inheritance, emphasizing the impact on neurodevelopment and cognitive function.