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This lecture covers the simulation of medical devices in neurosurgery, focusing on a thermal flowsensor for hydrocephalus. It discusses the effects of hydrocephalus, clinical treatments, and the development of a flowsensor using finite element analysis. The lecture also explores the validation process, sensor configurations, and the influence of sensor positioning. Additionally, it delves into the simulation of adolescent idiopathic scoliosis, including the use of numerical models for implant design and experimental testing. The lecture concludes with a discussion on the prediction of restenosis in angioplasty, highlighting the use of computational fluid dynamics and the assessment of arterial deformations.