This lecture covers the computation of boundary conditions in numerical flow simulations, including the importance of conformal and non-conformal meshes, handling unsteady problems with moving boundaries in inertial and non-inertial reference frames, and the use of sliding mesh and dynamic mesh techniques in Fluent. It also discusses the selection between pressure-based and density-based solvers in Fluent, the impact of spatial discretization on accuracy, running the solver with different initialization methods, checking convergence criteria, analyzing the solution through qualitative and quantitative methods, and improving the solution with adaptive mesh refinement. The lecture concludes with a summary emphasizing the influence of boundary conditions and numerical methods on convergence and computational resources.