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This lecture covers the basic principles of thermodynamics, focusing on the first and second principles, internal energy variation, heat exchange, and work supplied during transformations. It also delves into standard enthalpy of reactions, chemical equilibrium, and the enthalpy change in reactions. The instructor explains the concepts of enthalpy, heat of transformation, and the standard enthalpy of formation. Additionally, the lecture discusses the law of Hess, enthalpy calculations, and the enthalpy of reaction at constant pressure. Practical examples such as combustion reactions are used to illustrate these concepts.