Antibodies: Basics and Early Development

This lecture covers the basics and early development of antibodies, focusing on their structure, function, and diversity. It discusses the discovery of antibodies, the generation of antibody diversities, and the use of hybridoma technology to produce monoclonal antibodies. The lecture also explores the history of antibody activity discovery and the transition from polyclonal to monoclonal antibodies. It delves into the challenges of using animal antibodies and the development of human monoclonal antibodies. The lecture concludes with an overview of chimeric antibodies and their applications in various diseases.