Immunoengineering: Antibody Responses Modulation

This lecture by the instructor covers immunoengineering strategies to modulate antibody responses, focusing on precise antibody responses and immunodominance modulation. It delves into the immune system's role in providing protection against pathogens, the design strategies to influence antibody responses, and the challenges faced in vaccine development. The lecture also discusses the concept of immunodominance, particularly in the context of influenza as a case study, and explores the use of computational tools for protein design and the development of synthetic immunogens to guide antibody maturation. Additionally, it presents innovative approaches such as reverse vaccinology and the design of multi-site cocktail vaccines to elicit specific antibody responses.