Biomolecular Condensates: Forces and Structures

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Description

This lecture explores the construction of mathematical models for biomolecular condensates, focusing on membraneless organelles. It covers various forces such as direct and indirect forces, compartmentalization, and phase separation of Intrinsically Disordered Proteins. The lecture delves into the experimental manipulation of condensates and the classification of forces relevant in cells. It discusses the strength and length of chemical and physical bonds, as well as the role of indirect forces like entropic forces, membrane-mediated forces, and depletion forces. The lecture also touches upon the hydrophobic effect, self-assembly of proteins, and the formation of complex aggregates in water.

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