Morphogenesis: Tissue-Level Phenomena

This lecture by the instructor covers the tissue-level phenomena of morphogenesis, focusing on cell sorting by differential adhesion, cell migration, formation of tissue boundaries, convergent extension, tube formation, and branching morphogenesis. The presentation includes examples of engineered signaling centers for patterning human pluripotent stem cells and the self-organization of organoids. The lecture also delves into the role of morphogen gradients during early development and the manipulation of BMP4 concentration to influence cell fate. The instructor discusses the coordination of cell behaviors across tissue scales, emphasizing the importance of cellular mechanisms in morphogenesis.