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This lecture explores the rise of organoids and gastruloids through stem cell cultivation, focusing on the self-engineering of animal embryos. It delves into the potential applications of human stem cells in creating various tissues and organs, shedding light on the intricate process of tissue emergence during development. The presentation also discusses the mapping of gene space in the context of embryonic development, showcasing a single-cell resolution atlas of mouse gastrulation and early organogenesis.