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This lecture covers the basal ganglia circuitry involved in Parkinson's disease, including the structure and function of the basal ganglia, movement control, circuits, neurotransmitters, and the role of dopamine. It discusses the pathology of Parkinson's disease, the loss of dopamine, and the symptomatic treatments such as deep brain stimulation. The selective neuronal vulnerability, Lewy bodies, familial forms, spreading pathologies, and correlation with early symptoms are also explored.