Material Engineering in Cancer Immunotherapy

This lecture covers the means tumors use to evade immune pressure, the history of cancer immunotherapies, the concept and goal of drug delivery, and the strategies for systemic targeting, including passive and active targeting. It delves into the enhanced permeation and retention effect in tumors, nanoparticle characteristics, and the impact of nanoparticle size and shape on penetration in tumors. The lecture also discusses the use of tumor-targeted antibodies, the challenges of systemic cytokine administration, and the potential of nanoparticle immune agonists. It explores the use of hydrogels for drug delivery, the balance between immunity and toxicity in cancer immunotherapy, and the strategies for better drug release control in cancer treatment.