Lecture
This lecture covers various aspects of immune cell engineering, including the EPR effect for targeting, liposome formulation for cytokine delivery, and techniques for delivering checkpoint inhibitors. It also discusses the use of microneedles to enhance checkpoint blockade antibody therapy and the efficacy of aPD1 in treating mouse melanoma. The lecture explores the challenges and advancements in CAR-T cell therapy, such as choosing targets, combinatorial antigen recognition, and the associated cytokine release syndrome and neurotoxicity.