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This lecture delves into the intricate process of protein folding, exploring the formation of chemical bonds between amino acids and the emergence of polypeptide chains. The instructor discusses the translation of RNA messages into specific proteins at the ribosome, emphasizing the importance of the native state conformation. The lecture also covers the role of attractive forces in protein collapse and the unique compact conformations accessible. Various amino acids, their chemical properties, and the significance of their side chains in protein folding are explained. The lecture concludes with a discussion on the relationship between sequence, structure, and the number of protein folds over time.