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This lecture covers the microbial transformations involved in the sulfur cycle, focusing on sulfate-reducing bacteria (SRB) and their role in anaerobic environments. It discusses the pathways of sulfur cycling, the diversity of SRB, and the implications of their activities in biogeochemical processes. The lecture also explores the Sox pathway, chemolithotrophic growth, and the oxidation of sulfur compounds. Additionally, it addresses the environmental significance of sulfur-related processes, such as acid mine drainage and bioleaching, highlighting their impact on water quality and ecosystem health.