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This lecture introduces the fundamentals of supramolecular chemistry, covering cation and anion receptors, neutral molecule receptors, self-assembly processes, and molecular recognition. It explores the differences between organic and supramolecular synthesis, highlighting the importance of non-covalent bonds and weak chemical forces. The lecture delves into the concept of molecular machines, supramolecular catalysis, and the history of supramolecular chemistry. It also discusses the significance of hydrogen bonding, halogen bonding, cation-π interactions, and T-π interactions in forming supramolecular structures.