Total Synthesis: Hirsutellone B

In course

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Description

This lecture covers the total synthesis of Hirsutellone B, focusing on the strategies and reactions used by the instructor, including Nicolaou's approach, intramolecular D-A reactions, and the formation of macrocycles. Key tactics such as organocatalytic enantioselective epoxidation and Barton etherification are discussed, leading to the final product with a 1.2% overall yield.

Instructor

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Official source

https://mediaspace.epfl.ch/media/0_kbpw9u51

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