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This lecture covers the basics of genomics, including sequencing technologies, genome variation, and genome-wide association studies. It also delves into the history of genomics, highlighting key figures like James Watson, Walter Gilbert, and David Botstein. The lecture further explores human genetic linkage maps, RFLP methods, and the concept of genetic mapping using markers. The discussion extends to the detection of specific DNA sequences through Southern blotting and the significance of genetic maps in understanding gene order and recombination frequencies.