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This lecture covers the second and third principles of thermodynamics, the standard enthalpy of reaction, internal energy, and the energy of Gibbs. It explains the molecular interpretation of classical thermodynamics, state functions, and the first principle of thermodynamics. The lecture also delves into the concepts of system limits, equilibrium properties, and the study of chemical reactions. Various types of systems, energy conservation, and the calculation of enthalpy changes in reactions are discussed. Additionally, it explores exothermic and endothermic processes, enthalpy of state changes, and the application of Hess's law in determining reaction enthalpies.