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This lecture covers topics related to chromosomal dosage, genetic disorders, and inheritance patterns. It discusses cases of uniparental disomy, trisomy rescue, and the impact of chromosomal abnormalities on phenotype. The importance of balanced gene expression, hemoglobin structure, and electrophoresis techniques are also explained. Examples of autosomal recessive and dominant disorders, such as sickle-cell disease and Turner syndrome, are presented. The lecture concludes with a detailed explanation of X chromosome inactivation and its role in gene expression regulation.