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This lecture covers the concepts of reliability and redundancy in space systems, including definitions such as reliability, MTTF, MTBF, failure rate, and probability of failure. It also discusses equations related to reliability and redundancy, emphasizing the importance of constant and not time-dependent factors. An example with an interplanetary probe illustrates the application of these concepts. Furthermore, the lecture explores the safety design concept of the Space Shuttle, highlighting human rating, two-failure tolerance, quality build, quality control, inspections, and FMEA analysis.