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Lecture
Are you an EPFL student looking for a semester project?
Work with us on data science and visualisation projects, and deploy your project as an app on top of Graph Search.
This lecture covers the topic of Catalytic Asymmetric Reactions in Organic Chemistry, focusing on Dynamic Kinetic Asymmetric Transformation, Kinetic Resolution, and the switchable pathways controlled by NHC Cu cooperatively. The instructor discusses the motivation behind enantioselective Kinetic Resolution and Dynamic Kinetic Asymmetric Transformation, the reaction overview, the interaction between NHC and various metals, and the catalytic cycle of Copper Catalysis. The lecture also explores the substrate scope, the mechanism of the Palladium-catalyzed reaction, and the hydrogenation of carbonyl compounds and imines. The lecture concludes with the concept of switchable pathways, the cooperation of Cu(L) and NHC, and the general 'dormant/active' concept.