Catalytic Asymmetric Reactions in Organic Chemistry

This lecture covers the catalytic asymmetric reactions in organic chemistry, focusing on Chapters 4.2 and 4.3. It discusses the catalytic direct Mannich reaction catalyzed by proline, the amination of aldehydes and ketones, and the reversed approach of iminium activation with carboxylate for cyclopropanation. The mechanisms of various reactions, such as the Eder-Sauer-Wiechert-Hajos-Parrish reaction and the Mannich reaction, are explained in detail. Additionally, it explores the use of proline derivatives and other catalysts like binaphthyl scaffold for better selectivity in the Mannich reaction.