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This lecture discusses the comparison of stimulating waveforms in bioelectronics, evaluating their efficacy and safety. It covers various conditions causing charge imbalance in implants and potential solutions. The prevention of imbalance charge dc current and the concept of a window of safe operation are also explored. Additionally, the lecture delves into the challenges and solutions related to charge balancing current-mode stimulators, including the use of blocking capacitors and different techniques for achieving charge balance. The implications of thermal dissipation in implantable systems and strategies for stimulation bypassing are also addressed.